Drostanolone 150 ElitePharm 10ml

Drostanolone Steroid
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Drostanolone Steroid

Drostanolone is a classic anabolic steroid decades old, used back in the 1970s medically initially for women with breast cancer.

Now Drostanolone is very popular as a stable steroid as a cutting and hardening agent for bodybuilders in the last few weeks before they approach the show. In addition to other steroids that are used, this drug is classically used for its anti-estrogenic properties for that hard look. It’s thought to be a better more tolerated drug for cutting versus Winstrol for an example. For the issues that Winstrol might have on a drying agent that can lead to tears and muscle cramps. This thought to be a better hardening, the cutting agent that allows men to stay full and hard and train really strong as they’re going to that catabolic stage. Also, Drostanolone is used as an agent additionally as other steroids for men and women that just use steroids generally for personal use for a reason to improve their physique, lean muscle, stay fit, CrossFit, and powerlifting both on the professional and the amateur levels. Drostanolone is a moderately strong anabolic steroid theoretically with weak androgenic properties.

The History of Masteron

Drostanolone was first described in 1959 by Syntax. This is a pharmaceutical giant that brought us Anadrol and Supedrol. Entered the United States market by the FDA in the 1970s as a collaborative effort between Syntax and Lilly Pharmaceuticals. The FDA approved this agent Masteron for advanced inoperable breast cancer in women. Now, it’s very interesting that the package insert for physicians advised the physicians that Drostanolone was better tolerated by women versus testosterone because it was theoretically less virilizing with secondary male sex characteristics. I bring a point up here that it’s amazing that 50 years ago the medical experts in the world considered the quality of life. They were treating women with breast cancer and they knew that anabolic steroids had the property to protect women and we’ll discuss that on breast cancer and also brought to mind quality of life for these women. I just wonder today where that’s all gone in face of the attack of anabolic steroids, not for the scientific side but the political side.

Interesting that it was limited in medical use as other steroids were marketed more broadly across the board like Anadrol for an example for:

  • cachectic states secondary to medical disease;
  • pre and post-surgical agents;
  • osteoporosis;
  • and anemia.

This agent is only marketed for advanced inoperable breast cancer. That is amazing to me! The scope and limitation on this and we’ll see why. Due to other more improved therapies for women and breast cancer, Masteron was discontinued in the 1980s in America then subsequently in the 1990s in Belgium.

Now this drug is still one of the most popular drugs generically of course produced throughout the world and in very high demand. It comes in a Propionate and Enanthate form.

The chemical structure of Drostanolone

Masteron is a DHT-derived. The base structure is drostanolone. Drostanolone is a derivative of DHT with the addition of a methyl group that the carbon atom #2. Making this agent more anabolic as it’s increased its resistance to an enzyme called 3β-hydroxysteroid dehydrogenase, which is an enzyme that’s in muscle tissue that will break down agents like this anabolic steroids. Therefore setting it up that the threshold is lifted and it’s more anabolic. With the addition of a carboxylic acid ester, this increases the half-life of this versus a DHT straight derivative and it’s absorbed slower into the circulation the half-life of Masteron. Drostanolone’s half-life is approximately 2 days after the injection and this is similar to other propionate steroid esters. Also, Drostanolone comes in an Enanthate form that gonna have a longer half-life.

Anti-estrogenic Properties

The estrogenic properties of this steroid are as it is a nonaromatizable DHT-derived anabolic steroid. It acts as an anti-estrogen.

What is the mechanism of action? This is incredibly scientifically and clinically how it works.

1.It works like a Serm (selective estrogen receptor modulator) like Tamoxifen. Remember it was cleared by the FDA to be an anti-estrogen and it was used alongside Tamoxifen 50 years ago. And that is how it works. It’s blocking directly onto where estrogen effects and modulation the tissues, for example, breast cancer itself. There are receptors for estrogen receptor-positive breast cancer and it’s blocking it directly on that actual side.

2.This statement is controversial but I think it’s true. Drostanolone works directly on the aromatize enzyme. And is a competitive inhibitor leading to the reduction of systemic estrogen overall? Just like aromatase inhibitors like Anastrozole will do. This is incredible.

There are two theories that I apply.

  1. Directly on the aromatase inhibitor
  2. Indirectly as a selective estrogen receptor modulator.

And this is why you will see the theory of Masteron being used as an anti-estrogen with other estrogenic steroids like Testosterone, Dianabol and Equipoise. The limitation from this as I had is that it will work as an anti-estrogen but there is a limit to it. The limit is based:

  • on the amount of aromatized steroids that are used;
  • the duration;
  • the genes of the man;
  • other medical aspects;
  • and of course the cycle length.

Estrogenic side effects and using Masteron as a TRT add-on

Drostanolone does work. There’s no question.

It will reduce symptoms of gynecomastia

It will reduce systemic edema

It definitely initially has increased positive effects on the central nervous system (that’s mood and sex). And man can feel better on it. In the end, the problem is that it’s fleeting, and secondary to downregulation these effects are lost. That’s why men have to go on and off this steroid and it’s not sustained. The amazing feature is that it affects directly sex hormone-binding globulin or that it will reduce SHBG and therefore liberate free testosterone apart from the anti-estrogenic effects. And if you can imagine you do that to a man that’s on testosterone, he has increased free testosterone and that’s why the central nervous system will feel these effects. Of course, if the man has a mood disorder, depression, or some mania that can worsen as well.

The androgenic effects of Drostanolone

As Drostanolone is classified as a low androgenic side effect agent, it will lead to male pattern balding, acne, and of course, this is going to be based on the amount of use, the duration, your genetics, and so forth. Definitely, as I mentioned previously it affects the central nervous system with mood and sex and on the prostate. Very interesting. The prostate is affected by testosterone and DHT more so directly. The prostate will enlarge as a man gets older and that’s called BPH. And that’s can be very annoying it’s a nuisance for men and then we have to consider prostate cancer. We know, the date now shows that testosterone replacement itself will not cause prostate cancer but if the man has existing prostate cancer no question giving any androgen can further grow that and worse than that. It is interesting at this point of discussion I have to bring it to play that prostate disease and BPH all the way through prostate cancer you have to understand their estrogenic effects and receptors. So this is an anti-estrogenic drug if it’s utilized alongside steroids and testosterone itself with TRT could it have beneficial effects on a man’s prostate over his life. These are questions that I will be working on.

When we’re discussing androgenic effects we have to look at the suppressive effects of anabolic steroid-induced hypogonadism effects. Drostanolone although again is marketed and thought to be less suppressive. It can be very suppressive and men who come off it without PCT won’t feel well and depending on their history and other steroid use it can be a prolonged period of low testosterone or even a permanent period of low testosterone requiring androgen therapy for life. And this goes along with all of the other steroids. If this scares you and you have not done steroids or a limited amount of steroids be careful. Don’t use steroids. Because in my opinion is the most common and most crucial side effect to understand when using steroids that if you use steroids, you may lead to using more steroids, and at a certain point you’re gonna be on steroids which are testosterone for life. And that might be not the end of the world and you can still live a long and positive life.

Side effects of Masteron

Why Drostanolone is limited for prolong use? It’s not liver toxic. Cardiovascular disease aspects. It definitely will be directly and indirectly adverse to lipids where you lower HDL and potentially increase man’s LDL, depending on some other variables: his diet, his genes, family history of early coronary disease. Hypertension is interesting. Some men don’t get hypertension because it doesn’t lead to edema. Certainly depending on the dose they use, other steroids. But there can be men that get hypertensive because this is an anabolic steroid. There are receptors in the medial wall of the smooth muscle around the arteries that control blood pressure and if you get the overall vasoconstrictive effect that increases blood pressure. Again there are so many genes for this and so many multiply factors going on.

Men that used steroids long enough will enlarge the heart. That’s the left ventricle. That’s not good because at the end of the day if you live long enough your heart can enlarge just naturally because you’re living long enough, not to mention hypertension and coronary artery disease. So you want to be very careful with steroids.

It can lead to heart arrhythmias. By no means am I saying that anabolic steroids cause arrhythmias but there are no questions that in a multifactorial aspected manner that if you’re using steroids on top of whatever genes you have with other drugs not to mention that you could certainly pop into an arrhythmia? Hope it’s not a dangerous arrhythmia SVT is certainly not a great rhythm that anyone wants to have. I would like people to be aware that Drostanolone definitely affects every cell in the body that has receptors obviously for anabolic and androgenic receptors and the heart definitely does.

As I mentioned before Masteron affects your hormonal system with estrogen with free testosterone. It’s so complicated. Man can feel great but then man can get depressed and anxiety and as I mentioned before there is an interplay of anabolic steroid-induced hypogonadism it has to be considered and that’s for life.


So in conclusion with all the above Drostanolone is an incredibly powerful classic steroid that’s been around for decades and is not going anywhere. It’s got amazing properties that I’ve presented today. If you’re a man or a woman and you’re concerned about any of these side effects from hair loss to your heart, to your sex don’t do these steroids. Because it’s certainly in so many circumstances will lead to more steroids and more steroids. And although it’s not drugs and alcohol, it can lead to withdrawal symptoms and if you are a man being on testosterone for the rest of your life.

I really hope this helps.

1 review for Drostanolone 150 ElitePharm 10ml

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    Andy R

    Amazing cutting results. Used with Stanozolol also from Elite. Love this brand a lot.

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